Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation

Convergent use of phosphatidic acid for hepatitis C virus and SARS-CoV-2 replication organelle formation

Blog Article

Double membrane vesicles (DMV) are used as replication Lubricant organelles by several RNA viruses.Applying proteomics and lipidomics, Tabata and Prasad et al.find that two cellular acyltransferases (AGPAT1/2), responsible for synthesis of phosphatidic acid, play a role in the DMV-biogenesis of HCV Boot Seal and SARS-CoV-2, highlighting a common biogenesis mechanism for evolutionary distant positive-strand RNA viruses.